How Society’s View of Psychedelics is Changing

How Society’s View of Psychedelics is Changing

For decades, psychedelics were stigmatized as dangerous, mind-altering substances associated with the counterculture of the 1960s. However, a new wave of research is challenging these outdated perceptions, revealing psychedelics as powerful tools for mental health and personal growth. As more people explore their therapeutic benefits, society’s view of psychedelics is shifting. This article explores the changing narrative around psychedelics, the reasons behind this transformation, and what it means for the future.

  1. The Origins of the Stigma

The stigma surrounding psychedelics began in the 1960s when substances like LSD became associated with the counterculture movement. Government efforts to suppress this movement resulted in the criminalization of psychedelics and the promotion of misinformation.

  • The War on Drugs: Psychedelics were lumped together with dangerous drugs like heroin and cocaine during the War on Drugs. This led to decades of legal restrictions and negative public perception.
  • Misinformation: Fear-mongering and misinformation about psychedelics, including claims that they caused permanent mental illness or even death, further cemented their negative image.
  1. The Psychedelic Renaissance

In recent years, we’ve witnessed a resurgence in interest in psychedelics, often referred to as the “psychedelic renaissance.” Researchers, therapists, and individuals alike are rediscovering the potential of these substances for healing and personal growth.

  • Groundbreaking Research: Studies from prestigious institutions like Johns Hopkins University and Imperial College London have shown that psychedelics can be effective treatments for conditions like depression, anxiety, and PTSD.
  • Cultural Shifts: Public figures, including authors, scientists, and celebrities, are openly discussing their positive experiences with psychedelics, further shifting the narrative.
  1. Psychedelics in the Mainstream Media

The changing narrative around psychedelics has been reflected in the media, with documentaries, books, and podcasts shedding light on their potential benefits.

  • Documentaries: Films like Fantastic Fungi and How to Change Your Mind have educated the public about the science behind psychedelics and their potential for healing.
  • Celebrity Endorsements: Influential figures, from Silicon Valley entrepreneurs to Hollywood stars, have spoken about how psychedelics helped them with creativity, problem-solving, and mental health.
  1. Legalization and Decriminalization Movements

A significant factor in the changing perception of psychedelics is the push for decriminalization and legalization in many parts of the world. Cities like Denver and Oakland have decriminalContinuing Article 5: Breaking the Stigma: How Society’s View of Psychedelics is Changing

  1. Legalization and Decriminalization Movements (Continued)

A significant factor in changing public perception is the movement for the decriminalization and legalization of psychedelics. In cities like Denver, Oakland, and even states like Oregon, laws are being relaxed, allowing for the therapeutic use of substances like psilocybin. This shift is driven by mounting evidence of their therapeutic potential and a growing public demand for alternative treatments for mental health conditions.

  • Oregon’s Psilocybin Initiative: In 2020, Oregon became the first state to legalize psilocybin for therapeutic use. This marked a major milestone in the acceptance of psychedelics and signaled a broader societal shift toward more progressive drug policies.
  • Decriminalization vs. Legalization: Decriminalization involves removing criminal penalties for possession of small amounts of psychedelics, while legalization goes further by allowing regulated, supervised use in therapeutic settings. Both approaches aim to reduce stigma and improve access to these potentially life-changing treatments.
  1. The Role of Research in Shifting Perceptions

Scientific research has been instrumental in changing public views on psychedelics. Studies from top universities have provided compelling evidence of psychedelics’ efficacy in treating mental health disorders, leading to a reconsideration of their therapeutic potential.

  • Psilocybin for Depression: Research conducted at Johns Hopkins University and Imperial College London has shown that psilocybin can significantly alleviate symptoms of treatment-resistant depression, sometimes after just one session.
  • MDMA for PTSD: Clinical trials have demonstrated the efficacy of MDMA-assisted therapy for individuals suffering from PTSD, leading the FDA to designate MDMA as a “breakthrough therapy” for the condition.
  1. Psychedelics and Personal Growth

Beyond their potential for treating mental health conditions, many individuals are turning to psychedelics for personal growth and self-improvement. The altered states of consciousness facilitated by these substances can foster deep introspection, emotional healing, and enhanced creativity.

  • Spiritual Experiences: For some, psychedelics provide a profound sense of spiritual connection and a newfound appreciation for life. These experiences often leave lasting positive impacts on individuals, helping them break free from negative thought patterns.
  • Creative Breakthroughs: Many users report enhanced creativity and problem-solving abilities during and after psychedelic experiences. This has attracted the attention of professionals in creative fields, particularly in technology and art.
  1. Overcoming the Remaining Stigma

Despite the progress made, stigma surrounding psychedelics persists, particularly in more conservative regions and among those unfamiliar with the latest research. Overcoming this stigma requires continued public education, legislative reform, and a greater focus on responsible use.

  • Education and Advocacy: As more people become educated about the therapeutic benefits of psychedelics, the stigma will continue to decrease. Advocates and organizations like MAPS (Multidisciplinary Association for Psychedelic Studies) play a key role in disseminating accurate information and pushing for legal reform.
  • Responsible Use: Promoting responsible use and safe, guided experiences will help reduce the risks associated with psychedelics and foster a more balanced public perception.

Conclusion

The stigma surrounding psychedelics is gradually fading, thanks to scientific research, cultural shifts, and ongoing legalization movements. As more people discover the therapeutic and personal growth potential of psychedelics, society is beginning to embrace these substances as valuable tools for healing and self-improvement. However, continued efforts in education, research, and responsible use are essential for fully breaking the stigma and unlocking the potential of psychedelics for future generations.

The Therapeutic Potential of Psychedelic-Assisted Therapy

Introduction

In recent years, the field of mental health has witnessed a growing interest in psychedelic-assisted therapy. As studies reveal the transformative effects of psychedelics like psilocybin, LSD, and MDMA, mental health professionals are exploring their potential as therapeutic tools. By combining psychedelics with traditional therapy, patients suffering from conditions like depression, PTSD, and anxiety are finding new hope. This article delves into how psychedelic-assisted therapy works, its potential benefits, and the challenges that lie ahead.

  1. What is Psychedelic-Assisted Therapy?

Psychedelic-assisted therapy combines the controlled use of psychedelics with psychotherapy. The psychedelic is administered in a safe, supervised setting, allowing patients to confront emotions, traumas, and issues that may be difficult to access through traditional talk therapy.

  • How It Works: The patient ingests a psychedelic, and under the guidance of a trained therapist, they are encouraged to explore their emotions and thoughts.
  • Common Psychedelics Used: Substances like psilocybin, MDMA, and ketamine are among the most researched for therapeutic use. Each has its unique properties and potential applications in mental health care.
  1. Conditions Treated with Psychedelic Therapy

Psychedelic-assisted therapy has shown promise in treating a variety of mental health conditions, particularly those that have been resistant to conventional treatments.

  • Depression: Psilocybin has been studied extensively for its ability to alleviate symptoms of treatment-resistant depression. Patients report a sense of emotional release, greater insight into their depression, and improved mood.
  • PTSD: MDMA-assisted therapy has been particularly effective in treating PTSD. By reducing fear and increasing emotional openness, patients are able to process traumatic memories in a healthier, more integrated way.
  • Anxiety and End-of-Life Distress: Psilocybin therapy has been shown to reduce anxiety in patients facing terminal illnesses, providing a sense of peace and acceptance as they confront their mortality.
  1. The Science Behind Psychedelic Therapy

The effectiveness of psychedelic therapy lies in its ability to promote neuroplasticity and disrupt habitual patterns of thinking.

  • Neuroplasticity: Psychedelics like psilocybin and MDMA promote neuroplasticity, allowing the brain to form new connections and break free from rigid, maladaptive patterns.
  • Ego Dissolution and Emotional Healing: The temporary dissolution of the ego during a psychedelic session allows patients to experience their emotions without the usual defenses, facilitating deep emotional healing.
  1. Psychedelic Therapy in Practice

A typical psychedelic therapy session is highly structured, with careful attention to set and setting.

  • Set and Setting: The therapeutic environment is crucial to the success of the treatment. A calm, supportive setting allows the patient to feel safe and open to exploring their inner world.
  • Preparation and Integration: Patients undergo preparation sessions before taking the psychedelic, where they discuss their intentions, fears, and goals with the therapist. After the experience, integration sessions help the patient make sense of the experience and apply the insights gained to their daily life.
  1. Challenges and Considerations

While psychedelic-assisted therapy is showing great promise, it is not without challenges and risks.

  • Legal Barriers: Despite growing evidence of their therapeutic benefits, most psychedelics remain illegal in many parts of the world. This legal status limits access to treatment and hinders further research.
  • Risks: Psychedelics can induce challenging experiences, particularly in individuals with certain mental health conditions, such as schizophrenia. It’s crucial that these therapies are administered under professional supervision.
  1. The Future of Psychedelic-Assisted Therapy

The future of psychedelic-assisted therapy looks bright, with more clinical trials and research underway than ever before. As public perception shifts and legal barriers fall, psychedelics may soon become a mainstream treatment option for mental health conditions.

  • Expanding Access: Efforts are underway to make these treatments more accessible. Organizations like MAPS (Multidisciplinary Association for Psychedelic Studies) are leading the way in researching MDMA for PTSD and working toward FDA approval.
  • Psychedelic Clinics: In places like the Netherlands and Canada, clinics offering psychedelic therapy are already operating, providing a glimpse of what the future might hold for this field.

Conclusion

Psychedelic-assisted therapy is transforming the way we approach mental health treatment. With its ability to foster emotional healing and promote neuroplasticity, it offers hope to patients who have struggled to find relief through traditional methods. As research continues to advance and legal barriers diminish, the potential for psychedelics to revolutionize mental health care becomes more apparent.

Microdosing: A Balanced Guide for Beginners

Introduction

Microdosing—taking sub-perceptual doses of psychedelics like LSD or psilocybin—is gaining traction as a way to boost creativity, improve mood, and enhance focus without the intense hallucinations associated with larger doses. Advocates of microdosing claim it can lead to a range of benefits, from increased productivity to improved mental health. However, microdosing is not without its risks. This guide aims to provide beginners with a balanced overview of what microdosing entails, how to do it safely, and what potential benefits and downsides to expect.

  1. What Is Microdosing?

Microdosing involves taking a tiny, sub-threshold dose of a psychedelic, usually about one-tenth of a regular dose. The goal is to experience subtle improvements in mood, creativity, or focus without noticeable psychedelic effects like hallucinations or ego dissolution.

  • Typical Dosage: For psilocybin mushrooms, a microdose is typically around 0.1 to 0.3 grams, while for LSD, it is between 5 to 10 micrograms. These amounts are enough to alter brain chemistry without inducing a full-blown trip.
  • Popular Psychedelics for Microdosing: Psilocybin (magic mushrooms), LSD, and even cannabis are common substances used for microdosing. Some people also experiment with other substances like DMT or mescaline.
  1. Benefits of Microdosing

Although formal research on microdosing is still in its early stages, anecdotal evidence suggests that it may offer a range of benefits. Advocates claim that microdosing can lead to:

  • Enhanced Creativity and Problem-Solving: Many users report improved creative thinking and the ability to approach problems from new angles. This is particularly popular among artists, entrepreneurs, and tech workers.
  • Improved Mood and Emotional Well-Being: Microdosing is said to have mood-stabilizing effects, helping to reduce anxiety, alleviate mild depression, and foster a sense of well-being.
  • Better Focus and Productivity: Some users find that microdosing helps them stay more focused and productive throughout the day, without the jitteriness of caffeine or other stimulants.
  1. Risks and Downsides of Microdosing

While microdosing is generally considered safe, especially when compared to full doses of psychedelics, there are still some risks to consider.

  • Potential for Psychological Distress: Even at low doses, psychedelics can sometimes cause anxiety, paranoia, or uncomfortable emotions, especially if taken in an inappropriate setting.
  • Over-Reliance: Some users may become dependent on microdosing to maintain productivity or emotional stability, which can lead to issues if they stop or take higher doses.
  • Legal Risks: Psychedelics remain illegal in many parts of the world. While microdosing typically involves very small amounts, it’s still important to be aware of the legal risks involved.
  1. How to Start Microdosing: A Step-by-Step Guide

If you’re new to microdosing, it’s important to approach it mindfully and with a clear plan. Here’s a step-by-step guide to getting started:

  • Step 1: Choose Your Substance: Decide whether you’ll be microdosing with psilocybin, LSD, or another psychedelic. Be sure to research the appropriate dose for your chosen substance.
  • Step 2: Measure Your Dose: Accurate measurement is crucial. For psilocybin, invest in a scale that measures milligrams. For LSD, using blotter paper is common, but be cautious of uneven distribution.
  • Step 3: Schedule Your Doses: A common microdosing schedule is taking a dose every third day. This prevents tolerance from building up while allowing you to monitor how each dose affects you.
  • Step 4: Track Your Experience: Keep a journal to note how each dose affects your mood, creativity, and focus. This will help you fine-tune your regimen and identify any patternsContinuing with the third article and writing the next two as well:
  1. Managing Expectations in Microdosing

It’s essential to understand that the effects of microdosing are subtle and gradual. Unlike a traditional psychedelic experience, microdosing doesn’t result in immediate profound insights or intense visuals. The benefits, such as improved mood, creativity, or focus, tend to emerge gradually and can be hard to notice at first.

  • Patience is Key: Many microdosers report that it can take several weeks to notice significant improvements.
  • Set Realistic Goals: Microdosing isn’t a magic bullet. It can complement a healthy lifestyle but should not be seen as a standalone solution for mental health or productivity issues.
  1. Microdosing and Mental Health

While there’s growing anecdotal evidence supporting microdosing for mental health, it’s important to proceed with caution. Some people use microdosing to manage conditions like depression or anxiety, but without scientific consensus, there’s still much we don’t know.

  • Microdosing for Depression: Early studies show promise, but long-term effects are still unclear. Some users report enhanced mood and reduced anxiety, but others find it makes their symptoms worse.
  • Therapeutic Integration: For those using microdosing for mental health, pairing it with therapy or mindfulness practices can enhance the benefits and minimize risks.
  1. Legal and Ethical Considerations

Psychedelics are still illegal in many parts of the world, even in small quantities used for microdosing. It’s essential to stay informed about local laws and consider the ethical implications of using these substances, particularly when it comes to sourcing.

  • Legality: Some countries, like the Netherlands, allow the sale of truffles containing psilocybin, while in most places, psychedelics remain prohibited.
  • Ethical Sourcing: If you choose to microdose, ensure that your substances are sourced ethically and safely, avoiding products from exploitative or environmentally harmful practices.

Conclusion

Microdosing is a nuanced practice that offers potential benefits, from enhanced creativity to improved mood. However, it’s important to approach it with caution, realistic expectations, and a focus on safety. As interest in microdosing continues to grow, further research will help clarify its full range of effects and applications.

 

The Science Behind Psychedelics

How They Interact with the Brain

Introduction

Psychedelics have long been recognized for their ability to alter consciousness, but only recently have we begun to understand the neurological mechanisms behind these mind-bending experiences. Through scientific exploration, researchers have discovered how substances like LSD, psilocybin, and DMT interact with the brain, triggering profound shifts in perception, emotion, and cognition. This article dives into the intricate dance between psychedelics and the brain, unraveling the science behind their effects and exploring their potential for therapeutic use.

  1. The Role of Neurotransmitters in Brain Function

Neurotransmitters are the brain’s chemical messengers, transmitting signals between neurons to regulate everything from mood to motor function. Psychedelics primarily interact with serotonin, a neurotransmitter crucial for mood regulation, cognition, and perception.

  • Serotonin and Psychedelics: Many psychedelics, including LSD and psilocybin, are known as serotonin receptor agonists, meaning they bind to serotonin receptors, particularly the 5-HT2A receptor, which plays a key role in modulating mood and consciousness.
  • Impact on Brain Connectivity: When these substances bind to serotonin receptors, they disrupt the normal patterns of neural communication, leading to the altered states of consciousness associated with psychedelic experiences.
  1. Altered Brain Connectivity: The Default Mode Network

One of the most significant effects of psychedelics is their impact on the default mode network (DMN)—a brain network active during introspection and self-referential thinking. Psychedelics temporarily reduce the activity in this network, which is responsible for maintaining our sense of self or ego.

  • Ego Dissolution: When DMN activity decreases, people often experience “ego dissolution,” a phenomenon where the boundaries between self and the external world blur. This can lead to feelings of unity, spiritual experiences, or, in some cases, profound anxiety.
  • Increased Brain Connectivity: As the DMN quiets down, other regions of the brain start communicating more freely with each other. This increased connectivity explains the vivid visual hallucinations and the unusual thought patterns people experience while under the influence of psychedelics.

Recent brain-imaging studies using fMRI and EEG have shown that while under the influence of psychedelics, different regions of the brain that don’t typically communicate begin to form new connections. This leads to heightened creativity, novel problem-solving, and the breaking of old mental patterns.

  1. How Psychedelics Create Hallucinations

Hallucinations, one of the hallmark effects of psychedelics, are the result of the brain’s attempt to make sense of altered neural connectivity. The brain generates perceptions based on previous experiences, expectations, and internal states, but psychedelics disrupt this process.

  • Sensory Processing and Distortion: Psychedelics enhance activity in regions associated with sensory processing, leading to vivid visual and auditory experiences. Common hallucinations include geometric patterns, shifting colors, and even full-blown visions of people or places that feel real.
  • Synesthesia: Some users report synesthesia—a cross-wiring of senses—where they might “hear” colors or “see” sounds. This is a result of increased communication between sensory processing regions of the brain.
  1. The Role of Neuroplasticity in Psychedelic Healing

Neuroplasticity refers to the brain’s ability to reorganize itself by forming new neural connections. Psychedelics appear to promote neuroplasticity, making the brain more adaptable and better equipped to break negative patterns, such as those seen in depression or PTSD.

  • Psilocybin and Neuroplasticity: Research shows that psilocybin increases the growth of dendritic spines—small protrusions on neurons that help with the transmission of electrical signals. This could explain why psychedelics help with disorders that involve rigid, maladaptive thinking, like addiction or OCD.
  • MDMA and Trauma: MDMA, though technically not a classic psychedelic, helps foster neuroplasticity, which aids in emotional processing. By making traumatic memories less overwhelming, it allows individuals with PTSD to process and integrate their experiences in a healthier way.
  1. Psychedelics and Mental Health

The mental health crisis, particularly the rise in depression, anxiety, and PTSD, has led researchers to explore alternative treatments. Psychedelics, once stigmatized, are now being reexamined as potent therapeutic tools.

  • Psilocybin for Depression: Studies at institutions like Johns Hopkins University and Imperial College London have shown that psilocybin can lead to significant improvements in individuals with treatment-resistant depression. After a single dose, patients often report a sense of emotional release, greater insight into their issues, and improved mood.
  • MDMA for PTSD: The FDA has designated MDMA as a breakthrough therapy for PTSD. It helps patients process traumatic memories without being overwhelmed by negative emotions, thanks to its effects on the brain’s emotional centers, like the amygdala.
  1. Risks and Considerations in Psychedelic Therapy

Despite their potential, psychedelics are not without risks. The profound changes they induce can be overwhelming or frightening for some individuals, particularly those with preexisting mental health conditions like schizophrenia or bipolar disorder.

  • Set and Setting: The context in which psychedelics are taken can greatly influence the outcome. A supportive, therapeutic environment is essential for a positive experience. This is why psychedelic therapy involves careful preparation, monitoring, and integration of the experience.
  • Legal Considerations: Despite growing evidence for their benefits, most psychedelics remain illegal in many parts of the world. However, places like Oregon have decriminalized psilocybin and other cities are considering similar measures.
  1. The Future of Psychedelic Research

The future of psychedelic science is bright, with more clinical trials and studies underway than ever before. Researchers are exploring how psychedelics can help with not just mental health disorders, but also addiction, eating disorders, and chronic pain.

  • Expanding Applications: Beyond treating mental health conditions, researchers are investigating whether psychedelics can enhance creativity, foster innovation, and even promote spiritual well-being. Fields like neuroscience, psychology, and even philosophy are likely to see significant advancements thanks to psychedelic research.
  • Ongoing Studies: Universities like Harvard and Yale are expanding their psychedelic research programs, studying the effects of DMT, LSD, and psilocybin on various aspects of brain function and mental health.

Conclusion

Psychedelics interact with the brain in ways that we are only beginning to understand, from their impact on serotonin receptors to their promotion of neuroplasticity and altered brain connectivity. Their therapeutic potential is vast, and as research expands, so too does our appreciation of these substances’ ability to heal mental health conditions. However, responsible use, guided by science and supported by legal reform, is essential for unlocking their full benefits.

  1. Altered Brain Connectivity: The Default Mode Network

One of the most significant effects of psychedelics is their impact on the default mode network (DMN)—a brain network active during introspection and self-referential thinking. Psychedelics temporarily reduce the activity in this network, which is responsible for maintaining our sense of self or ego.

  • Ego Dissolution: When DMN activity decreases, people often experience “ego dissolution,” a phenomenon where the boundaries between self and the external world blur. This can lead to feelings of unity, spiritual experiences, or, in some cases, profound anxiety.
  • Increased Brain Connectivity: As the DMN quiets down, other regions of the brain start communicating more freely with each other. This increased connectivity explains the vivid visual hallucinations and the unusual thought patterns people experience while under the influence of psychedelics.

Recent brain-imaging studies using fMRI and EEG have shown that while under the influence of psychedelics, different regions of the brain that don’t typically communicate begin to form new connections. This leads to heightened creativity, novel problem-solving, and the breaking of old mental patterns.

  1. How Psychedelics Create Hallucinations

Hallucinations, one of the hallmark effects of psychedelics, are the result of the brain’s attempt to make sense of altered neural connectivity. The brain generates perceptions based on previous experiences, expectations, and internal states, but psychedelics disrupt this process.

  • Sensory Processing and Distortion: Psychedelics enhance activity in regions associated with sensory processing, leading to vivid visual and auditory experiences. Common hallucinations include geometric patterns, shifting colors, and even full-blown visions of people or places that feel real.
  • Synesthesia: Some users report synesthesia—a cross-wiring of senses—where they might “hear” colors or “see” sounds. This is a result of increased communication between sensory processing regions of the brain.
  1. The Role of Neuroplasticity in Psychedelic Healing

Neuroplasticity refers to the brain’s ability to reorganize itself by forming new neural connections. Psychedelics appear to promote neuroplasticity, making the brain more adaptable and better equipped to break negative patterns, such as those seen in depression or PTSD.

  • Psilocybin and Neuroplasticity: Research shows that psilocybin increases the growth of dendritic spines—small protrusions on neurons that help with the transmission of electrical signals. This could explain why psychedelics help with disorders that involve rigid, maladaptive thinking, like addiction or OCD.
  • MDMA and Trauma: MDMA, though technically not a classic psychedelic, helps foster neuroplasticity, which aids in emotional processing. By making traumatic memories less overwhelming, it allows individuals with PTSD to process and integrate their experiences in a healthier way.
  1. Psychedelics and Mental Health

The mental health crisis, particularly the rise in depression, anxiety, and PTSD, has led researchers to explore alternative treatments. Psychedelics, once stigmatized, are now being reexamined as potent therapeutic tools.

  • Psilocybin for Depression: Studies at institutions like Johns Hopkins University and Imperial College London have shown that psilocybin can lead to significant improvements in individuals with treatment-resistant depression. After a single dose, patients often report a sense of emotional release, greater insight into their issues, and improved mood.
  • MDMA for PTSD: The FDA has designated MDMA as a breakthrough therapy for PTSD. It helps patients process traumatic memories without being overwhelmed by negative emotions, thanks to its effects on the brain’s emotional centers, like the amygdala.
  1. Risks and Considerations in Psychedelic Therapy

Despite their potential, psychedelics are not without risks. The profound changes they induce can be overwhelming or frightening for some individuals, particularly those with preexisting mental health conditions like schizophrenia or bipolar disorder.

  • Set and Setting: The context in which psychedelics are taken can greatly influence the outcome. A supportive, therapeutic environment is essential for a positive experience. This is why psychedelic therapy involves careful preparation, monitoring, and integration of the experience.
  • Legal Considerations: Despite growing evidence for their benefits, most psychedelics remain illegal in many parts of the world. However, places like Oregon have decriminalized psilocybin and other cities are considering similar measures.
  1. The Future of Psychedelic Research

The future of psychedelic science is bright, with more clinical trials and studies underway than ever before. Researchers are exploring how psychedelics can help with not just mental health disorders, but also addiction, eating disorders, and chronic pain.

  • Expanding Applications: Beyond treating mental health conditions, researchers are investigating whether psychedelics can enhance creativity, foster innovation, and even promote spiritual well-being. Fields like neuroscience, psychology, and even philosophy are likely to see significant advancements thanks to psychedelic research.
  • Ongoing Studies: Universities like Harvard and Yale are expanding their psychedelic research programs, studying the effects of DMT, LSD, and psilocybin on various aspects of brain function and mental health.

Conclusion

Psychedelics interact with the brain in ways that we are only beginning to understand, from their impact on serotonin receptors to their promotion of neuroplasticity and altered brain connectivity. Their therapeutic potential is vast, and as research expands, so too does our appreciation of these substances’ ability to heal mental health conditions. However, responsible use, guided by science and supported by legal reform, is essential for unlocking their full benefits.

The Evolution of Psychedelics: From Ancient Rituals to Modern Healing

 The Evolution of The Evolution of Psychedelics: From Ancient Rituals to Modern Healing

Introduction

The story of psychedelics stretches back millennia, transcending continents, cultures, and spiritual practices. These substances, revered by ancient civilizations, have shaped both human consciousness and healing traditions. Today, psychedelics are emerging as powerful tools in modern medicine, offering hope to those suffering from mental health disorders. From ancient shamanic rituals to cutting-edge psychiatric therapies, the journey of psychedelics mirrors humanity’s quest for healing and transcendence. Let’s explore how these substances evolved from sacred rites to clinical treatments, uniting the old and the new.

  1. Psychedelics in Ancient Civilizations

Psychedelic use in human history is deep-rooted. Cultures like the indigenous peoples of the Amazon and Mesoamerica utilized natural psychedelics like Ayahuasca, Peyote, and Psilocybin mushrooms for religious ceremonies and healing.

  • Ayahuasca in the Amazon: The brew, made from Banisteriopsis caapi and other plants, has been used by shamans for centuries to connect with spirits, heal trauma, and receive guidance.
  • Mesoamerican Psilocybin Rituals: Ancient civilizations such as the Aztecs and Mayans used psilocybin mushrooms in religious ceremonies. They believed these fungi allowed them to communicate with gods.
  • Siberian Shamanism: Siberian shamans utilized Amanita muscaria mushrooms to induce altered states, seeking spiritual insights and healing.

These ancient uses formed the foundation of how psychedelics were understood—not just as recreational drugs, but as sacred medicines.

  1. The Middle Ages and Early Exploration

During the Middle Ages, the knowledge of psychedelic plants faded in Western cultures. However, indigenous groups continued their traditional uses, keeping their spiritual and healing practices alive. With European exploration in the 15th and 16th centuries, accounts of “magic plants” and psychedelic rituals began to emerge, but they were often misunderstood or dismissed by explorers and missionaries.

  • Colonial Suppression: In many cases, the Church and colonizers suppressed indigenous psychedelic use, labeling it witchcraft or heresy.
  • Rediscovery by Western Scholars: By the early 20th century, Western anthropologists and explorers, such as Richard Evans Schultes, began documenting these practices again, laying the groundwork for the psychedelic renaissance.
  1. The 20th-Century Psychedelic Renaissance

The modern reawakening of psychedelics began in the mid-20th century. Scientists, psychologists, and counterculture figures embraced these substances for their potential to expand consciousness, heal trauma, and explore the mind.

  • Albert Hofmann’s Discovery of LSD: In 1943, Swiss chemist Albert Hofmann accidentally discovered the effects of LSD, sparking interest in its potential for both scientific study and spiritual exploration.
  • Psilocybin in the West: In 1957, the work of R. Gordon Wasson introduced psilocybin mushrooms to the West. His article in Life magazine, “Seeking the Magic Mushroom,” ignited curiosity and led to further research into their effects.
  • 1960s Counterculture Movement: The 1960s saw psychedelics explode into popular culture, with figures like Timothy Leary advocating for their use to expand consciousness. However, the subsequent backlash from governments led to the prohibition of most psychedelics by the early 1970s.
  1. The War on Drugs and Psychedelic Prohibition

The global War on Drugs launched in the 1970s largely erased the emerging acceptance of psychedelics in both popular culture and research. Governments around the world classified substances like LSD, psilocybin, and DMT as Schedule I drugs, claiming they had no accepted medical use and a high potential for abuse.

  • Stigma and Misinformation: The public perception of psychedelics became clouded by misinformation, linking them to dangerous behavior and mental health problems.
  • Impact on Research: Psychedelic research virtually came to a halt, with few scientists able to secure funding or approval to continue exploring their potential therapeutic benefits.
  1. The Modern Resurgence of Psychedelics in Medicine

The early 2000s marked the dawn of a new era for psychedelics. As mental health crises, including depression, PTSD, and anxiety, grew more severe, researchers began revisiting these substances for their potential to offer breakthroughs in therapy.

  • Clinical Trials and Studies: Recent studies have shown promising results in using psilocybin and MDMA to treat conditions like depression, anxiety, and PTSD.
    • Johns Hopkins University has conducted pioneering research into psilocybin for depression and end-of-life anxiety, yielding positive outcomes.
    • MAPS (Multidisciplinary Association for Psychedelic Studies) has led the way in researching MDMA for PTSD, bringing it closer to FDA approval.
  • Therapeutic Models: Psychedelic-assisted psychotherapy is gaining momentum, combining controlled psychedelic experiences with guided therapy to help patients confront trauma and heal.
  1. Cultural and Legal Shifts

As research on the therapeutic benefits of psychedelics grows, so too does public acceptance. Many areas are revisiting their legal frameworks, with some countries and states decriminalizing or even legalizing certain psychedelics.

  • Decriminalization Movements: Cities like Denver and Oakland have decriminalized psilocybin, while Oregon has become the first U.S. state to legalize the use of psilocybin in supervised therapeutic settings.
  • Psychedelic Retreats and Healing Centers: Countries like Peru and Costa Rica are home to Ayahuasca retreats, offering people a chance to experience psychedelic healing in traditional settings.
  1. The Future of Psychedelics

The future of psychedelics looks promising, with increasing recognition of their therapeutic potential. As legal barriers fall and research expands, psychedelics may become integral to modern medicine, particularly in the treatment of mental health disorders.

  • Potential for New Treatments: Ongoing research into psychedelics could lead to novel therapies for conditions like addiction, eating disorders, and chronic pain.
  • Global Shifts: As stigma fades and evidence grows, the integration of psychedelics into mainstream medicine and spiritual practices seems inevitable.

Conclusion

The evolution of psychedelics is a testament to their enduring significance in human culture and healing. From ancient rituals to cutting-edge therapies, psychedelics have the potential to bridge the gap between spiritual well-being and scientific innovation. As we move forward, the lessons of the past and the promise of the future are guiding us toward a deeper understanding of these extraordinary substances.

Exploring the Mind-Altering World of Psychedelics: A Comprehensive Definition and Guide

Exploring the Mind-Altering World of Psychedelics: A Comprehensive Definition and Guide

Welcome to the mind-altering world of psychedelics. In this comprehensive definition and guide, we will embark on a journey through various dimensions of consciousness, exploring the profound effects of psychedelic substances on the human mind.

Psychedelics have captivated the curiosity of scientists, psychologists, and spiritual seekers for decades. From the mystical experiences reported by ancient cultures to the groundbreaking research conducted today, these substances continue to offer a unique window into the depths of human perception.

In this article, we will delve into the different categories of psychedelics, such as psilocybin mushrooms, LSD, and DMT, uncovering their origins, effects, and potential therapeutic applications. We will also discuss the risks and precautions associated with their use, providing a balanced view of their benefits and potential pitfalls.

Whether you are a seasoned psychonaut or someone simply intrigued by these mind-expanding substances, this article will serve as a valuable resource for understanding the world of psychedelics. Join us as we unravel the mysteries and discover the transformative power within these fascinating compounds.

What are psychedelics?

Psychedelics, also known as hallucinogens, are a class of psychoactive substances that can profoundly alter perception, mood, and consciousness. These mind-altering compounds work by interacting with the brain’s serotonin receptors, particularly the 5-HT2A receptor, which is responsible for regulating various cognitive and sensory processes.

Psychedelics are characterized by their ability to induce altered states of consciousness, often described as “trips” or “journeys.” These experiences can range from the profoundly spiritual and introspective to the visually stunning and euphoric. The effects of psychedelics can vary widely depending on the specific substance, dosage, set (the user’s mindset and expectations), and setting (the physical and social environment).

While the term “psychedelics” is often used interchangeably with “hallucinogens,” it’s important to note that not all hallucinogens are psychedelics. Hallucinogens can be divided into two main categories: psychedelics and dissociatives. Psychedelics, such as LSD, psilocybin, and DMT, are known for their ability to enhance sensory perception, evoke vivid imagery, and facilitate introspective experiences. Dissociatives, on the other hand, are characterized by their ability to induce a sense of detachment from one’s physical body and surroundings, often leading to a feeling of “out-of-body” experiences.

History of psychedelics

The use of psychedelics has a long and fascinating history, dating back thousands of years. Ancient cultures around the world have long recognized the transformative power of these substances, incorporating them into religious and spiritual practices.

One of the earliest known uses of psychedelics can be traced back to the ancient Aztec and Mayan civilizations, where the psilocybin-containing “magic mushrooms” were revered for their mind-altering properties. Similarly, the indigenous peoples of the Amazon rainforest have used the DMT-containing ayahuasca brew for centuries, employing it in shamanic rituals and healing ceremonies.

In the 20th century, the scientific community began to take a closer look at the potential of psychedelics. In the 1940s, Swiss chemist Albert Hofmann discovered the psychoactive properties of LSD, which he later synthesized and experimented with. This led to a surge of research into the therapeutic and consciousness-expanding effects of psychedelics, with scientists exploring their potential applications in psychiatry, psychotherapy, and the study of human consciousness.

However, the recreational use and growing popularity of psychedelics in the 1960s, particularly LSD, led to a backlash and the eventual criminalization of these substances in many countries. This largely halted scientific research and exploration of psychedelics for several decades, until a recent resurgence of interest and renewed scientific investigations in the past two decades.

Different types of psychedelics

Psychedelics encompass a diverse range of substances, each with its own unique chemical structure and effects on the mind and body. Here are some of the most well-known and studied psychedelics:

Psilocybin Mushrooms

Psilocybin mushrooms, commonly referred to as “magic mushrooms,” are a genus of fungi that contain the psychoactive compounds psilocybin and psilocin. These mushrooms have been used for centuries in various cultural and spiritual practices, particularly in Central America and Mexico. When ingested, psilocybin mushrooms can induce vivid visual hallucinations, altered perceptions of time and space, and a profound sense of introspection and connection with the natural world.

SD (Lysergic Acid Diethylamide)

LSD, or lysergic acid diethylamide, is a synthetic psychedelic compound derived from ergot, a fungus that grows on rye and other grains. LSD is known for its potent psychoactive effects, which can include intense visual hallucinations, heightened sensory perception, and a profound alteration of consciousness. LSD was extensively researched in the mid-20th century for its potential therapeutic applications, but its recreational use and associated counterculture movement led to its criminalization in many countries.

T (Dimethyltryptamine)

DMT, or dimethyltryptamine, is a naturally occurring psychedelic compound found in various plant species and even produced endogenously in the human body. When consumed, DMT can induce a powerful, short-lived psychedelic experience characterized by intense visual hallucinations, a sense of ego dissolution, and a profound feeling of connection with the divine or the “spiritual realm.” DMT is the primary active ingredient in the Amazonian brew known as ayahuasca, which has been used for centuries in indigenous shamanic practices.

MDMA (3,4-Methylenedioxymethamphetamine)

While not strictly a psychedelic, MDMA (also known as ecstasy or molly) is a synthetic drug that shares some similarities with psychedelics. MDMA is classified as an empathogen, meaning it can enhance feelings of empathy, emotional connection, and social bonding. In addition to its recreational use, MDMA has shown promise in the treatment of various mental health conditions, such as post-traumatic stress disorder (PTSD) and social anxiety.

How psychedelics work in the brain

Psychedelics exert their mind-altering effects by interacting with the brain’s complex neurochemical systems, particularly the serotonin (5-HT) receptor network. Serotonin is a neurotransmitter that plays a crucial role in regulating various physiological and psychological processes, including mood, perception, and cognition.

The primary mechanism of action for most psychedelics involves binding to the 5-HT2A receptor, which is highly expressed in the prefrontal cortex, a region of the brain responsible for higher-order cognitive functions, decision-making, and emotional processing. When psychedelics bind to these receptors, they can trigger a cascade of neurochemical changes that result in the characteristic alterations in perception, mood, and consciousness.

In addition to the 5-HT2A receptor, psychedelics may also interact with other serotonin receptors, as well as other neurotransmitter systems, such as the dopaminergic and glutamatergic systems. These complex neurobiological interactions contribute to the diverse range of psychedelic experiences, which can vary significantly depending on the specific substance, dosage, and individual neurophysiology.

Neuroimaging studies have revealed that psychedelics can induce profound changes in brain connectivity and network dynamics, leading to a temporary “disintegration” of the brain’s default mode network. This network is typically responsible for maintaining our sense of self and our habitual patterns of thinking and behavior. By disrupting this network, psychedelics can facilitate a more fluid and flexible state of consciousness, allowing for new perspectives and insights to emerge.

The effects of psychedelics on perception and consciousness

The most striking and profound effects of psychedelics are often observed in the realm of perception and consciousness. These substances have the remarkable ability to profoundly alter an individual’s subjective experience of reality, leading to a heightened awareness and a deeper connection with one’s inner and outer worlds.

One of the hallmark effects of psychedelics is the enhancement of sensory perception. Users often report experiencing a heightened sensitivity to visual, auditory, and tactile stimuli, with colors appearing more vibrant, sounds becoming more nuanced, and physical sensations feeling more intense. This amplification of sensory input can lead to the experience of synesthesia, where senses become intertwined, and individuals may “hear” colors or “see” sounds.

In addition to the perceptual changes, psychedelics can also induce a profound shift in one’s sense of self and consciousness. Users often report a sense of ego dissolution, where the boundaries between the self and the external world become blurred, leading to a feeling of oneness with the universe or a deeper connection with the divine. This altered state of consciousness can facilitate introspective insights, emotional breakthroughs, and a renewed sense of meaning and purpose.

The subjective experience of psychedelics can also be characterized by a distorted sense of time, with users often reporting that time appears to slow down or even stand still. This altered perception of time can contribute to a sense of timelessness and a heightened appreciation for the present moment.

Potential benefits of using psychedelics

Despite the historical stigma and legal restrictions surrounding psychedelics, there is a growing body of research highlighting their potential therapeutic benefits in various domains, including mental health, addiction treatment, and personal growth.

One of the most promising areas of psychedelic research is in the treatment of mental health conditions, such as depression, anxiety, and post-traumatic stress disorder (PTSD). Studies have shown that psychedelics, particularly psilocybin and MDMA, can help alleviate symptoms and improve overall well-being in patients suffering from these debilitating disorders. The therapeutic potential of psychedelics lies in their ability to facilitate introspection, emotional processing, and the integration of traumatic experiences.

Treatment

Psychedelics have also shown promise in the treatment of addiction, including alcoholism and nicotine dependence. The profound experiences and insights facilitated by psychedelics can help individuals gain a deeper understanding of their addictive behaviors and motivate them to make positive changes in their lives. Additionally, psychedelics may help to “reset” the brain’s reward pathways, reducing cravings and improving overall well-being.

d Spiritual Exploration

Beyond the clinical applications, psychedelics have long been used for personal growth, self-exploration, and spiritual development. The altered states of consciousness induced by these substances can facilitate a sense of connection with the divine, a deeper understanding of one’s place in the universe, and a renewed appreciation for the interconnectedness of all things. This can lead to positive changes in an individual’s values, priorities, and overall outlook on life.

Creativity and Problem-Solving

Some researchers have also explored the potential of psychedelics to enhance creativity and problem-solving abilities. By disrupting habitual patterns of thinking and opening the mind to new perspectives, psychedelics may facilitate the emergence of novel ideas, innovative solutions, and a more flexible and adaptive mindset.

Risks and potential side effects of psychedelics

While the potential benefits of psychedelics are significant, it is crucial to acknowledge the risks and potential side effects associated with their use. Responsible and informed use is essential when exploring these mind-altering substances.

Psychological Risks

One of the primary concerns with psychedelics is the potential for adverse psychological reactions, such as anxiety, panic attacks, and psychotic episodes, particularly in individuals with pre-existing mental health conditions or a predisposition to mental illness. The “bad trip” phenomenon, where users experience intense fear, paranoia, or a sense of losing control, can be a significant risk, especially in unprepared or unsupported settings.

Physical Risks

Psychedelics can also pose physical risks, including increased heart rate, blood pressure, and body temperature, as well as the potential for nausea, vomiting, and dehydration. In rare cases, psychedelics have been linked to the onset of underlying medical conditions, such as cardiovascular or neurological problems.

-Term Risks

The long-term effects of psychedelics are not yet fully understood, and there is a need for more longitudinal research to determine the potential for lasting cognitive, emotional, or neurological changes. Additionally, the use of psychedelics in an uncontrolled or unsupervised setting can increase the risk of legal consequences, such as arrest or incarceration.

indications and Interactions

It is crucial to consider the potential contraindications and drug interactions when using psychedelics, as they may interact with certain medications, medical conditions, or other substances, potentially leading to adverse or even dangerous outcomes.

Legal status of psychedelics around the world

The legal status of psychedelics varies significantly around the world, reflecting the complex and often controversial nature of these substances.

and Criminalization

In many countries, including the United States, most psychedelics are classified as Schedule I or II controlled substances, meaning they are considered to have a high potential for abuse and no accepted medical use. Possession, cultivation, and distribution of these substances are generally illegal and can result in severe criminal penalties.

Decriminalization and Legalization Efforts

However, there has been a growing movement towards the decriminalization and legalization of certain psychedelics, particularly psilocybin and MDMA, in recognition of their potential therapeutic benefits. Some jurisdictions, such as Oregon and several cities in the United States, have taken steps to decriminalize the possession and use of these substances for personal consumption.

Regulated Medical and Research Use

In a few countries, such as the Netherlands and Switzerland, the use of psychedelics is permitted for medical and research purposes under strict regulatory frameworks. This allows for the controlled and supervised administration of these substances, primarily for the treatment of mental health conditions and the advancement of scientific understanding.

Indigenous and Traditional Use

In some regions, the traditional and ceremonial use of psychedelics, such as ayahuasca in the Amazon basin, is recognized and protected, reflecting the cultural and spiritual significance of these substances for indigenous communities.

How to safely use psychedelics

For individuals interested in exploring the world of psychedelics, it is essential to prioritize safety and responsible use. Here are some key considerations for safely using psychedelics:

and Setting

The “set and setting” is a crucial factor in determining the quality and outcome of a psychedelic experience. Set refers to the user’s mindset, including their expectations, intentions, and emotional state. Setting refers to the physical and social environment in which the experience takes place. Ensuring a comfortable, supportive, and controlled setting can minimize the risk of adverse reactions.

Dosage and Purity

Accurate dosing and the purity of the substance are crucial for a safe and enjoyable experience. It is essential to start with a low dose and gradually increase as needed, rather than taking a high dose initially. Obtaining psychedelics from trusted and reputable sources can help ensure the purity and potency of the substance.

Preparation and Integration

Proper preparation, including research, education, and the development of a supportive network, can significantly enhance the psychedelic experience. Additionally, the integration of insights and experiences gained during the psychedelic journey is crucial for translating the benefits into lasting personal growth and positive changes.

Supervision and Guidance

For those new to psychedelics or those with pre-existing mental health conditions, the presence of a trained guide or facilitator can provide invaluable support and ensure a safe and productive experience. These individuals can help navigate the psychedelic journey and offer guidance during challenging moments.

Harm Reduction Practices

Incorporating harm reduction practices, such as testing the substance for purity, having a sober companion present, and being aware of potential interactions with other medications or substances, can further mitigate the risks associated with psychedelic use.

Conclusion: Exploring the future of psychedelics

As we delve deeper into the captivating world of psychedelics, it is clear that these mind-altering substances hold immense potential for transforming our understanding of consciousness, mental health, and the human experience. From the ancient spiritual practices of indigenous cultures to the cutting-edge scientific research of today, psychedelics continue to capture the imagination and curiosity of individuals across the globe.

The future of psychedelics holds both promise and challenge. As the scientific community continues to unravel the complex neurobiological mechanisms underlying the effects of these substances, we may witness the development of innovative therapeutic approaches for a wide range of mental health conditions. At the same time, the legal and regulatory landscape surrounding psychedelics remains a complex and ever-evolving landscape, requiring careful consideration and thoughtful policymaking.

Ultimately, the exploration of psychedelics invites us to embrace the profound and often humbling nature of the human mind. By expanding our understanding of consciousness and the depths of our own subjective experiences, we may unlock new pathways for personal growth, spiritual enlightenment, and the betterment of the human condition. As we continue to navigate this captivating world, let us do so with an open mind, a deep sense of responsibility, and a reverence for the mysteries that lie within.

Where do magic mushrooms grow?

How to Find Psychedelic Mushrooms

Photo of mushrooms growing in moss

Psilocybin mushrooms are an all-time psychonaut favorite, and rightfully so. They belong to a class of psychedelics called entheogens – this word was coined to describe their immensely spiritual properties and purpose, and can be translated to something along the lines of “manifesting divinity.”

There is evidence to suggest that psychedelic mushrooms have been used ritually by Aztecs, Mayas, and other ancient Mesoamerican cultures, and perhaps many thousands of years before that by aboriginal Saharan tribes in North Africa. According to Terence McKenna, psilocybin might actually be responsible for the development of our creativity hundreds of thousands of years ago.

In any case, humans have been connecting with the divine via magic mushrooms for a long time, and this tradition has carried on into the modern age. However, in this modern age, possession and use of shrooms is forbidden by law in most of the world. The question poses itself – how and where to find magic mushrooms? Without further ado, below are a few of the most accessible ways to source them.

We’ve written about psilocybin mushrooms here, in our Essential Guide.

PICK THEM YOURSELF

Finding psychedelic mushrooms might not be as tricky as you’d think. The first place where you should consider looking for them is probably the most obvious one – your own backyard.

Psilocybin mushrooms are abundant in nature. If you live in the right place, you can get quite lucky during their fruiting season. However, you need to be seriously acquainted with the different strains that grow in your area. It’s a well-known fact that mushrooms come in all shapes and sizes, as well as in various levels of toxicity. Some can cause mild poisoning, while others can be quite deadly. At times, the differences in their appearance are minute, but you need to be sure that what you’re picking won’t be the end of you.

Where do magic mushrooms grow?

The number one element all fungi need for growth is moisture. Dry air and wind can easily kill them. They also require a certain temperature, which is specific for each species, and fertile soil full of nutrients such as sugar, starch, lignin, fats, protein, and nitrogen.

If there is a right amount of nutrients in tree bark, fallen leaves, dung, mulch, or compost, you will find mushrooms happily sprouting on the surface. They don’t necessarily need a dark environment, but the absence of light does help the air retain its moisture. This is why densely forested areas close to big bodies of water usually provide suitable conditions, so it’s a good place to start looking for them.

Animal dung (especially cow dung) is about as nutritious a growing environment as it gets – if the humidity is right, it’s highly probable to spot them growing from it.

Where to find magic mushrooms

You can find psychedelic mushrooms quite commonly throughout North America, especially on the West Coast, in the northeast of the continent, and around the Gulf of Mexico. Mexico itself and most of Central America are brimming with them, and so are some South American countries, such as Ecuador, Colombia, Brazil, Venezuela, and Argentina.

Hawaii seems to be a paradise not just for holidays – some world-class strains come from these ancient islands. Other locations abundant with shrooms are South Africa, the east coast of Australia, South India, the Philippines, and pretty much the whole coastal region of Southeast Asia.

Oh, and you can find shrooms growing all over Europe, too.

Global Distribution of over 100 species of psychedelic mushrooms. From: Guzmán G, Allen JW, Gartz J (1998). A worldwide geographical distribution of the neurotropic fungi, an analysis and discussion

So, if you are feeling up for some foraging, odds are that there are fresh magic shrooms growing somewhere close by. But, again – make sure to become extremely familiar with all the types of mushrooms growing in your area, their effect and appearance. Erowid has a valuable resource for identifying the trippy ones and Shroomery has a thorough list of all the species of psilocybin shrooms you can find growing in countries around the world and states around the USA. Mycotopia is also a great online community where you can consult with fellow shroomheads about anything you might be curious or concerned about.

How to identify magic mushrooms

There is an incredible variety of mushroom species in general, and the same goes for the psilocybin-containing ones. So far, there are some 227 accepted and classified species, 53 of which grow in Mexico, 22 in the USA and Canada, 19 in Australia and the eastern islands, 16 in Europe and 15 in Asia. Some of these species overlap in terms of where they grow, some are endemic to certain areas and conditions.

There is no single feature based on which magic mushrooms can be distinguished from regular ones. They come in many shapes, sizes, and colors, and the only way to truly differentiate them is to know their appearance well, and get experience in mushroom hunting.

A good strategy to start with is to get familiar with the most common species of psychedelic shrooms available in the wild. Here are the top five to get you started off:

1) Psilocybe cubensis and Psilocybe subcubensis

Psilocybe Cubensis in its natural habitat

Psilocybe cubensis and Psilocybe subcubensis are two species that can be found in tropical zones throughout the world. The former are much more common, and are the most well-known species of magic mushrooms, whereas the latter are not as abundant, but can be found growing in the same areas. Their appearance is also very similar: they are classic stubby-stemmed parasol-shaped mushrooms with predominantly light-to-golden-brownish caps that are bulbous before fruiting, and flat and wide in diameter when fully mature. A certain kind of P. cubensis is known worldwide as the “Golden Teacher”.

2) Psilocybe semilanceata

Psilocybe semilanceata
Psilocybe semilanceata/ Zinnmann / CC BY-SA 3.0

Psilocybe semilanceata might be the most widely available psychedelic shrooms. You are likely to be able to find them if you live in Europe, North and South America, Asia, Australia, and New Zealand. They also go by the name “Liberty Caps”, because of their dark bell-shaped tops. Their stems are slim, and can be wavy.

3) Psilocybe cyanescens

Psilocybe cyanescens
Psilocybe cyanescens / Caleb Brown / CC BY-SA 3.0

Psilocybe cyanescens are quite easily recognized due to their undulating tops. For this reason, they are commonly referred to as “Wavy Caps”. They are among the most potent magic mushrooms in existence, reaching a whopping 1.96% of active compound content by dry weight in North America. They also cover a decent array of latitudes, and can be found on the West Coast of the USA, south of the Bay Area, in Central and Western Europe, New Zealand, and parts of Western Asia.

4) Panaeolus or Copelandia cyanescens

Copelandia cyanescens
Copelandia cyanescens / Alan Rockefeller / CC BY-SA 4.0

Also known as the “Hawaiian” shrooms, these are not the most distinct species, with long, slim stems and light brown to light grey caps. However, in terms of their effect, they are up there with the greats. They grow all over the world: in south North America and north South America, Western Europe, Central Africa, South and Southeast Asia and throughout Oceania.

5) Psilocybe azurescens

Psilocybe azurescens

Psilocybe azurescens are endemic to the West Coast of the USA, specifically to Oregon and Washington. They earn a spot in the top five for having almost the highest concentration of psilocybin out of any magic mushroom species you can find: up to 1.80%. In addition, they have an incredible amount of baeocystin, which is a chemical analog of psilocybin. Compared to P. cubensis, they can contain up to ten times more of this compound by dry weight, which puts them among the most potent magic mushrooms in existence. They are also quite beautiful shrooms, sporting a slim stem and a convex caramel-colored cap with a conical top.

GROWING MAGIC MUSHROOMS

If you’re not enticed by the prospect of a gathering quest that may result in misidentification-induced poisoning, or if you live in an area where it’s impossible to find magic mushrooms, you’ll be happy to know that there is an accessible alternative: growing shrooms on your own is relatively easy to do! Even better than that: growing mushrooms provides for a year-round supply, enables you to try strains from all over the world, and – the best part – if you live in the US (but not in CA, GA, or ID), buying spores is legal because they don’t yet contain psilocybin or psilocin, the active psychedelic elements. If you live in NM, even growing the mushrooms is legal! Look into our detailed guide on the legality status of mushrooms around the world for more info.

There are two ways to go about it – you can either order an uninoculated grow kit and spores online, or make your own substrate from scratch. The first option is the easier one – if your material came from a reputable vendor and there was no contamination, all it will take from you is to keep the grow kit in a dark and humid place. However, we do recommend that you go DIY with this project – it’s more fun, you learn more from it, and it can yield better results. Luckily, The Third Wave has prepared a thorough and easy-to-follow guide on how you can do just this.

BUY THEM IN COUNTRIES WHERE THEY’RE LEGAL

A third option would be to consult our guide on the international legality of psilocybin, and to find somewhere close to you where you can safely and legally buy, or otherwise procure, and consume them.

If you’re in Europe, you have quite a few choices: the Netherlands, Austria, Czech Republic, Spain, and Portugal. The Netherlands, of course, outlawed psilocybin mushrooms back in 2008, but magic truffles are perfectly legal to purchase and consume. If this piques your interest, be sure to check out our guide to the differences between magic mushrooms and magic truffles. As for the rest of the countries, psilocybin has undergone decriminalization, which means that it’s either alright to possess small amounts for personal use.

In the case that you are looking for a more structured setting in which to try psilocybin in a legal and guided manner, you can consider a guided psilocybin retreat  with Synthesis, our trusted partner, in Amsterdam.

That’s all there is to it. This article should contain enough info to get you started on your mushroom-sourcing venture. Make sure to obey the law and stay safe in your search, and, as always, in your psychonautical endeavors.

Do Canadians have a constitutional right to magic mushrooms?

Do Canadians have a constitutional right to magic mushrooms?

Psilocybin mushrooms in a grow room in a farm in Hazerswoude, central Netherlands.
Canada has to consider whether magic mushrooms are a medical right
By Olivia Goldhill

Science reporter

Where cannabis first trod, magic mushrooms are sure to follow. A Canadian therapist has asked Health Canada to permit the use of psilocybin, the psychedelic ingredient in magic mushrooms, for medical reasons. If denied, he’s planning to file a lawsuit, claiming the health department’s decision would violate Canadians’ right to “life, liberty, and security of person”—an argument that previously convinced Canadian courts that it is unconstitutional to prohibit medical access to cannabis.

Therapist Bruce Tobin said he submitted an application with Health Canada in March, asking for approval to treat cancer patients’ end-of-life anxiety with psilocybin. Magic mushrooms are illegal under Canada’s Controlled Drug and Substances Act, but the law has a clause, Section 56(1), which states that the Health Minister may exempt substances if necessary for medical or scientific purposes. Tobin is planning to give Health Canada to the end of the year to respond and, if they don’t, will file a motion in federal court asking for a judicial review. If his argument is denied there, he plans to go all the way to the Supreme Court.

“There have been several landmark cannabis cases in which the High Courts have delivered very explicit judgement that Canadian citizens have the right to autonomy in making healthcare decisions with regards to life and death medical conditions,” said Tobin. Early research has shown that psilocybin therapy is effective at treating end-of-life anxiety. Tobin says he has patients who’ve tried all the alternatives and are in “abject misery,” and he wants them to have access to psilocybin.

Tobin isn’t the only one pushing against Canada’s legal system. Dana Larsen, who founded a medical cannabis dispensary in 2007, announced he was launching a medical psilocybin dispensary in June. The dispensary is based in Vancouver and claims to mail psilocybin microdoses to people with a documented medical need; Larsen lists anxiety, cluster headaches, and pain as conditions that can be treated with psilocybin.

Like Tobin, Larsen hopes medical use of psilocybin will be legalized. But whereas Tobin is applying for legal recognition first (“I’ve chosen to stay on the legal side of the fence and establish legality before I get charged,” he said), Larsen isn’t prepared to wait. So far, he hasn’t faced much legal trouble. In a statement to Vice, Vancouver police spokesman Steve Addison said the police was aware of the dispensary in June and would look into it. “We continue to focus our enforcement energy towards combating organized and sophisticated criminals who profit from the production and distribution of harmful drugs, such as fentanyl and other opioids,” Addison said.

Constitutional challenge is not the only way to legalize medical psilocybin; the more conventional route is to simply conduct enough experiments for the drug to be approved by health authorities. This process is currently ongoing for psilocybin, with a stage three trial (the most advanced necessary for medical approval) underway in North America and Europe on psilocybin as treatment for depression. In October 2018, the US Food and Drug Administration gave the trial “breakthrough therapy designation”, meaning the study will be hastened through the drug-development process, and suggesting the FDA is inclined to approve psilocybin as medication if the stage three results are strong.

But stage three trials are necessarily large and, in the case of psilocybin therapy, it takes time to train enough therapists to carry out the treatment. Tobin says that, until the stage three trials are completed, legalizing psilocybin by constitutional challenge would provide psilocybin to those who need it most. Though his legal challenge could take several years if it proceeds to the Supreme Court, Tobin believes he’ll see success under judicial review. By the end of 2020, he believes medical psilocybin will be a recognized constitutional right in Canada.

Lysergic Acid Diethylamide and Mystical Experiences

Lysergic Acid Diethylamide and Mystical Experiences

Michael Lyvers, in Neuropathology of Drug Addictions and Substance Misuse, 2016

Abstract

Lysergic acid diethylamide (LSD) is the best-known drug of a subtype of hallucinogens, commonly referred to as psychedelics. LSD is by far the most potent psychedelic and one of the most potent psychoactive substances ever discovered. This chapter reviews the current state of knowledge about LSD, focusing on the theory of LSD actions in brain, the ability of the drug to elicit mystical/religious experiences, the risks of LSD use, past therapeutic applications, the colorful history of LSD, its myriad influences on Western culture, and future prospects for this controversial mind-changing chemical.

Drugs of abuse

Amitava Dasgupta, in Alcohol, Drugs, Genes and the Clinical Laboratory, 2017

Abuse of hallucinogens

LSD was first synthesized by Albert Hofmann in 1938 and then its psychedelic effect was discovered in 1943. Lysergic acid is found naturally in the parasitic fungus C. purpurea. Although LSD was a popular recreational drug in 1960s, today its abuse is less common. A moderate dose of 75–150 μg of LSD can produce psychedelic effects (optimum dosage used for recreational purpose is 100–200 μg). Traumatic experience (bad trips) may also occur from LSD abuse. LSD also alters the state of consciousness as well as impairing psychomotor functions. The biochemical action of LSD is due to its partial agonistic property of serotonin receptors 5-hydroxytryptamine (5-HT) especially 5-HT2A receptors. Although LSD abuse can result in severe toxicity, there is no documented death due to abuse of LSD alone. LSD is completely absorbed after ingestion and psychological effects are observed 30–45 min after ingestion. In humans, LSD is also rapidly metabolized into structurally similar metabolites [46]. The major metabolite is 2-oxo-3-hydroxy lysergic acid, which is present in human urine 16–43 times greater than LSD [47].

Toxicology and the clinical laboratory of LSD

Toxicology and the clinical laboratory of LSD

 

Lysergic acid diethylamide

Lysergic acid diethylamide (LSD) is synthesized from d-lysergic acid, a naturally occurring ergot alkaloid found in the fungus Claviceps purpurea, which grows on wheat and other grains. LSD shares structural features with serotonin (5-hydroxytryptamine; a major CNS neurotransmitter and neuromodulator) [81]. LSD binds to serotonin receptors in the CNS and acts as a serotonin agonist. The principal psychological effects of LSD are perceptual distortions of color, sound, distance, and shape (synesthesia); depersonalization and loss of body image; and rapidly changing emotions from ecstasy to depression or paranoia. The physiologic effects of LSD are related to its sympathomimetic actions and include mydriasis (most frequent and consistent), tachycardia, increased body temperature, diaphoresis, and hypertension; at higher doses, parasympathomimetic actions may be observed [e.g., salivation, lacrimation, nausea, and vomiting (muscarinic actions)]. Neuromuscular effects may include paresthesia, muscle twitches, and incoordination (nicotinic actions) [81].

LSD is used illicitly because of its hallucinogenic effects. The most common adverse effects of LSD are panic attacks. In addition, unpredictable recurrence of hallucinations (flashbacks) may occur weeks or months after last drug use, and LSD may elicit psychotic reactions. No evidence suggests that repeated LSD use results in dependence or withdrawal symptoms [81].

Popular dosage forms include powder, gelatin capsule, tablet, and LSD-impregnated sugar cubes, filter paper, or postage stamps. The drug is rapidly absorbed from the GI tract; the effects begin within 40–60 minutes, peaking at ~2–4 hours, and subside by 6–8 hours. The elimination t1/2 is ~3 hours. The metabolism of LSD in humans is incompletely understood, but 2-oxo-3-hydroxy-LSD is present in urine at concentrations of 10- to 43-fold greater than LSD [82]. N-demethyl-LSD is also present in urine specimens, but at concentrations approximately equivalent to those of LSD [83].

The typical dose is low (20–80 μg) and is rapidly metabolized, and only ~1%–2% of the drug is excreted unchanged in urine. Thus detection of LSD presents an especially difficult analytical challenge. Even with sensitive assays, the detection window for LSD is generally only 12–24 hours [84]. Immunoassays are targeted to detect LSD, and confirmation assays may be performed by GC–MS, GC–MS/MS, LC–MS/MS, or LC–MS [16].